Blar i SINTEF Open på forfatter "Schmid, Ruth Baumberger"
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A comparative biodistribution study of polymeric and lipid-based nanoparticles
Åslund, Andreas; Vandebriel, Rob J.; Caputo, Fanny; de Jong, Wim H.; Delmaar, Christiaan; Hyldbakk, Astrid; Rustique, Emilie; Schmid, Ruth Baumberger; Snipstad, Sofie; Texier, Isabelle; Vernstad, Kai; Borgos, Sven Even F. (Peer reviewed; Journal article, 2022)Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical ... -
Identification of novel cyanoacrylate monomers for use in nanoparticle drug delivery systems prepared by miniemulsion polymerisation – A multistep screening approach
Hyldbakk, Astrid; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Åslund, Andreas; Klinkenberg, Geir; Nakstad, Vu; Wågbø, Ane Marit; Schmid, Ruth Baumberger; Molesworth, Peter Patrick (Peer reviewed; Journal article, 2022)Poly (alkyl cyanoacrylate) (PACA) polymeric nanoparticles (NPs) are promising drug carriers in drug delivery. However, the selection of commercially available alkyl cyanoacrylate (ACA) monomers is limited, because most ... -
Interlaboratory evaluation of a digital holographic microscopy–based assay for label-free in vitro cytotoxicity testing of polymeric nanocarriers
Marzi, Anne; Eder, Kai Moritz; Barroso, Álvaro; Wågbø, Ane Marit; Mørch, Ýrr Asbjørg; Hatletveit, Anne Rein; Visnes, Torkild; Schmid, Ruth Baumberger; Klinkenberg, Geir; Kemper, Björn; Schnekenburger, Jürgen (Peer reviewed; Journal article, 2022)State-of-the-art in vitro test systems for nanomaterial toxicity assessment are based on dyes and several staining steps which can be affected by nanomaterial interference. Digital holographic microscopy (DHM), an ... -
Magnetic-Responsive Carbon Nanotubes Composite Scaffolds for Chondrogenic Tissue Engineering
Saranya, Muthusamy; da Silva, Aldeliane M.; Karjalainen, Hanna; Klinkenberg, Geir; Schmid, Ruth Baumberger; McDonagh, Birgitte Hjelmeland; Molesworth, Peter Patrick; Sigfúsdóttir, Margrét S.; Wågbø, Ane Marit; Santos, Susana. G.; Couto, Cristiana; Karjalainen, Ville-Pauli; Gupta, Shuvashis Das; Järvinen, Topias; de Roy, Luisa; Seitz, Andreas. M.; Finnilä, Mikko; Saarakkala, Simo; Haaparanta, Anne Marie; Janssen, Lauriane; Lorite, Gabriela S. (Peer reviewed; Journal article, 2023)The demand for engineered scaffolds capable of delivering multiple cues to cells continues to grow as the interplay between cell fate with microenvironmental and external cues is revealed. Emphasis has been given to develop ... -
Subcellular detection of PEBCA particles in macrophages: combining darkfield microscopy, confocal Raman microscopy, and ToF-SIMS analysis
Vennemann, Antje; Breitenstein, Daniel; Tallarek, Elke; Mørch, Ýrr Asbjørg; Schmid, Ruth Baumberger; Wiemann, Martin (Peer reviewed; Journal article, 2022)The detection of biomedical organic nanocarriers in cells and tissues is still an experimental challenge. Here we developed an imaging strategy for the label-free detection of poly (ethylbutyl cyanoacrylate) (PEBCA) ... -
Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors
Anthiya, Shubaash; Oztürk, Süleyman Can; Yanik, Hamdullah; Tavukcuoglu, Ece; Sahin, Adem; Datta, Dhrubajyoti; Charisse, Klaus; Álvarez, David Moreira; Loza, María Isabel; Calvo, Alfonso; Sulheim, Einar; Loevenich, Simon; Klinkenberg, Geir; Schmid, Ruth Baumberger; Manoharan, Muthiah; Esendağlı, Güneş; Jose Alonso, Maria (Peer reviewed; Journal article, 2023)K-RAS is a highly relevant oncogene that is mutated in approximately 90% of pancreatic cancers and 20–25% of lung adenocarcinomas. The aim of this work was to develop a new anti-KRAS siRNA therapeutic strategy through the ...